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eBay-Artikelnr.:125579627542
Artikelmerkmale
- Artikelzustand
- Pages
- 391
- Publication Date
- 2010-02-04
- Subject
- Biology
- ISBN
- 9789048134649
Über dieses Produkt
Product Identifiers
Publisher
Springer Netherlands
ISBN-10
9048134641
ISBN-13
9789048134649
eBay Product ID (ePID)
78332314
Product Key Features
Number of Pages
IX, 391 Pages
Publication Name
Comparative Biology of Aging
Language
English
Publication Year
2010
Subject
Gerontology, Life Sciences / Cell Biology, Experiments & Projects, Life Sciences / Zoology / Mammals, Research, Geriatrics
Type
Textbook
Subject Area
Social Science, Science, Medical
Format
Hardcover
Dimensions
Item Weight
29.8 Oz
Item Length
9.3 in
Item Width
6.1 in
Additional Product Features
Intended Audience
Scholarly & Professional
Dewey Edition
22
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
571.87819
Table Of Content
Introduction: Lifespans and Pathologies Present at Death in Laboratory Animals.- Animal Size, Metabolic Rate, and Survival, Among and Within Species.- Hormonal Influences on Aging and Lifespan.- Exploring Mechanisms of Aging Retardation by Caloric Restriction: Studies in Model Organisms and Mammals.- Cell Replication Rates In Vivo and In Vitro and Wound Healing as Affected by Animal Age, Diet, and Species.- Sirtuin Function in Longevity.- The Role of TOR Signaling in Aging.- Mitochondria, Oxidative Damage and Longevity: What Can Comparative Biology Teach Us?.- Comparative Genomics of Aging.- Changes in Lysosomes and Their Autophagic Function in Aging: The Comparative Biology of Lysosomal Function.- Telomeres and Telomerase.- Cardiac Aging.- Comparative Skeletal Muscle Aging.- Aging of the Nervous System.- Aging of the Immune System Across Different Species.
Synopsis
determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2-4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32-38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25]., determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2-4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32-38 days 3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals 25]., Dealing with every one of the mammalian species that are employed in laboratory research, this book provides details comparative data for age-related changes in its subjects. It does so at the level of the whole animal, its organs, organelles and molecules.
LC Classification Number
R850.A1-854
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