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eBay-Artikelnr.:145525260336
Artikelmerkmale
- Artikelzustand
- Book Title
- Model-Assisted Bayesian Designs for Dose Finding and Optimization
- ISBN
- 9780367146245
Über dieses Produkt
Product Identifiers
Publisher
Taylor & Francis Group
ISBN-10
036714624X
ISBN-13
9780367146245
eBay Product ID (ePID)
3057248134
Product Key Features
Subject
Clinical Medicine
Publication Year
2022
Number of Pages
232 Pages
Language
English
Publication Name
Model-Assisted Bayesian Designs for Dose Finding and Optimization : Methods and Applications
Type
Textbook
Subject Area
Medical
Format
Hardcover
Additional Product Features
LCCN
2022-017949
Dewey Edition
23/eng/20220801
Dewey Decimal
615.1/9
Synopsis
Bayesian adaptive designs provide a critical approach to improve the efficiency and success of drug development that has been embraced by the US Food and Drug Administration (FDA). This is particularly important for early phase trials as they form the basis for the development and success of subsequent phase II and III trials. The objective of this book is to describe the state-of-the-art model-assisted designs to facilitate and accelerate the use of novel adaptive designs for early phase clinical trials. Model-assisted designs possess avant-garde features where superiority meets simplicity. Model-assisted designs enjoy exceptional performance comparable to more complicated model-based adaptive designs, yet their decision rules often can be pre-tabulated and included in the protocol--making implementation as simple as conventional algorithm-based designs. An example is the Bayesian optimal interval (BOIN) design, the first dose-finding design to receive the fit-for-purpose designation from the FDA. This designation underscores the regulatory agency's support of the use of the novel adaptive design to improve drug development. Features Represents the first book to provide comprehensive coverage of model-assisted designs for various types of dose-finding and optimization clinical trials Describes the up-to-date theory and practice for model-assisted designs Presents many practical challenges, issues, and solutions arising from early-phase clinical trials Illustrates with many real trial applications Offers numerous tips and guidance on designing dose finding and optimization trials Provides step-by-step illustrations of using software to design trials Develops a companion website (www.trialdesign.org) to provide freely available, easy-to-use software to assist learning and implementing model-assisted designs Written by internationally recognized research leaders who pioneered model-assisted designs from the University of Texas MD Anderson Cancer Center, this book shows how model-assisted designs can greatly improve the efficiency and simplify the design, conduct, and optimization of early-phase dose-finding trials. It should therefore be a very useful practical reference for biostatisticians, clinicians working in clinical trials, and drug regulatory professionals, as well as graduate students of biostatistics. Novel model-assisted designs showcase the new KISS principle: Keep it simple and smart!
LC Classification Number
RM301.25
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Verkäuferbewertungen (175'326)
- 0***4 (1)- Bewertung vom Käufer.Letzter MonatBestätigter KaufI received my purchase on time as promised which I appreciated. I brought 2 nursing books and the condition of both books where great!!!! They were clean, great shape,and ready to use!!! I cannot tell you the value of finding your books for so much cheaper in good condition when your on a tight budget!!! Exceptional!!!
- 0***a (126)- Bewertung vom Käufer.Letzter MonatBestätigter KaufPerfect
- u***n (30)- Bewertung vom Käufer.Letzter MonatBestätigter KaufExactly as was described!