Psychiatric Pharmacogenomics - Hardcover By Mrazek, David A. - GOOD

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MPN
Does not apply
ISBN
9780195367294
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Über dieses Produkt

Product Identifiers

Publisher
Oxford University Press, Incorporated
ISBN-10
0195367294
ISBN-13
9780195367294
eBay Product ID (ePID)
77959666

Product Key Features

Number of Pages
280 Pages
Publication Name
Psychiatric Pharmacogenomics
Language
English
Subject
Psychiatry / Psychopharmacology, Pharmacology, Psychiatry / General
Publication Year
2010
Type
Textbook
Subject Area
Medical
Author
David A. Mrazek
Format
Hardcover

Dimensions

Item Height
1.1 in
Item Weight
21.6 Oz
Item Length
6.3 in
Item Width
9.3 in

Additional Product Features

Intended Audience
Scholarly & Professional
LCCN
2009-027407
Dewey Edition
22
eBook Format
Unspecified
Reviews
"Psychiatric Pharmacogenomics, authored by David A. Mrazek, M.D., F.R.C. Psych., is the most authoritative book in the field of psychiatric genetics produced in the XXI Century. This text is not only an ideal tool for the busy clinician, but also offers the knowledge required by educators and investigators in the field of psychiatry pharmacogenomics at large".--Pedro Ruiz, MD, President, American Psychiatric Association (2006-2007); President Elect, World Psychiatric Association (2008-2011); and Professor of Psychiatry and Vice Chair for Education, Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, Texas"In his book on psychiatric pharmacogenomics, Dr. Mrazek distils his scientific wisdom with clinical insights, to produce a unique guide to the theory and practice of this nascent specialty. He takes us on a journey of discovery, from the initial perplexing observations that different patients respond differently to the same medication in the same dose, to our understanding that this differential responsiveness could often be due to common genetic variation...This is a timely and hugely important book, pulling together the strands of psychiatric pharmacogenomics in an accessible way that provides clear guidance to clinicians, and is also an invaluable review of contemporaneous research for scientists working in the field."--David H. Skuse, MD, Behavioral and Brain Sciences Unit, Institute of Child Health, London, UK"This textbook - a pioneer in this field - offers a useful and actual overview on pharmacogenetic testing in psychiatry and is especially dedicated to clinicians and practicing psychiatrists rather than scientists working in the field of pharmacogenomics."--Julia Kirchheiner, MD, Professor of Clinical Pharmacology, University of Ulm, Institute of Pharmacology of Natural Products & Clinical Pharmacology, Ulm, Germany"This remarkable volume should be read by all those who regularly prescribe psychotropic medication and more generally by those interested in how rapid scientific advances in molecular genomics and in the study of psychopathology together have led to major new resources for the treatment of mental illness. Dr. Mrazek's text is the first to comprehensively address psychiatric pharmacogenomics. The book is superbly written. This book is a rare combination of superb scientific writing, thoughtful clinical reflection, and profound understanding of this rapidly advancing field and should be read by all those concerned about the effects of mental illness in families. --William R. Beardslee, MD, Director, Baer Prevention Initiatives and Chairman Emeritus, Department of Psychiatry, Children's Hospital Boston, Gardner/Monks Professor of Child Psychiatry, Harvard Medical School, Boston, MA"This is an exciting book on the use of genetic testing for predicting adverse effects of, as well as response to, psychopharmacologic agents. The author, a pioneer in pharmacogenomics, has written an extremely informative book for clinicians and researchers. It is a very welcome addition to the psychiatric literature...This is a superb book on a very useful topic in clinical psychiatry. All psychiatrists need to be versed in the wisdom this book provides. " --Doody's 2010 PROSE Award Honorable Mention recipient, Biological Sciences "It would quite useful as a reference text to be utilized when a patient presents with a history of side effects from low doses of medications or nonresponse to medication. I hope that Dr Mrazek will have some mechanism to provide updates as this field advances." -- Psychiatrist.com, "Psychiatric Pharmacogenomics, authored by David A. Mrazek, M.D., F.R.C. Psych., is the most authoritative book in the field of psychiatric genetics produced in the XXI Century. This text is not only an ideal tool for the busy clinician, but also offers the knowledge required by educators and investigators in the field of psychiatry pharmacogenomics at large".--Pedro Ruiz, MD, President, American Psychiatric Association (2006-2007); President Elect, World Psychiatric Association (2008-2011); and Professor of Psychiatry and Vice Chair for Education, Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, Texas "In his book on psychiatric pharmacogenomics, Dr. Mrazek distils his scientific wisdom with clinical insights, to produce a unique guide to the theory and practice of this nascent specialty. He takes us on a journey of discovery, from the initial perplexing observations that different patients respond differently to the same medication in the same dose, to our understanding that this differential responsiveness could often be due to common genetic variation...This is a timely and hugely important book, pulling together the strands of psychiatric pharmacogenomics in an accessible way that provides clear guidance to clinicians, and is also an invaluable review of contemporaneous research for scientists working in the field."--David H. Skuse, MD, Behavioral and Brain Sciences Unit, Institute of Child Health, London, UK "This textbook - a pioneer in this field - offers a useful and actual overview on pharmacogenetic testing in psychiatry and is especially dedicated to clinicians and practicing psychiatrists rather than scientists working in the field of pharmacogenomics."--Julia Kirchheiner, MD, Professor of Clinical Pharmacology, University of Ulm, Institute of Pharmacology of Natural Products & Clinical Pharmacology, Ulm, Germany "This remarkable volume should be read by all those who regularly prescribe psychotropic medication and more generally by those interested in how rapid scientific advances in molecular genomics and in the study of psychopathology together have led to major new resources for the treatment of mental illness. Dr. Mrazek's text is the first to comprehensively address psychiatric pharmacogenomics. The book is superbly written. This book is a rare combination of superb scientific writing, thoughtful clinical reflection, and profound understanding of this rapidly advancing field and should be read by all those concerned about the effects of mental illness in families. --William R. Beardslee, MD, Director, Baer Prevention Initiatives and Chairman Emeritus, Department of Psychiatry, Children's Hospital Boston, Gardner/Monks Professor of Child Psychiatry, Harvard Medical School, Boston, MA, "Psychiatric Pharmacogenomics, authored by David A. Mrazek, M.D., F.R.C. Psych., is the most authoritative book in the field of psychiatric genetics produced in the XXI Century. This text is not only an ideal tool for the busy clinician, but also offers the knowledge required by educators and investigators in the field of psychiatry pharmacogenomics at large".--Pedro Ruiz, MD, President, American Psychiatric Association (2006-2007); President Elect, World Psychiatric Association (2008-2011); and Professor of Psychiatry and Vice Chair for Education, Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, Texas "In his book on psychiatric pharmacogenomics, Dr. Mrazek distils his scientific wisdom with clinical insights, to produce a unique guide to the theory and practice of this nascent specialty. He takes us on a journey of discovery, from the initial perplexing observations that different patients respond differently to the same medication in the same dose, to our understanding that this differential responsiveness could often be due to common genetic variation...This is a timely and hugely important book, pulling together the strands of psychiatric pharmacogenomics in an accessible way that provides clear guidance to clinicians, and is also an invaluable review of contemporaneous research for scientists working in the field."--David H. Skuse, MD, Behavioral and Brain Sciences Unit, Institute of Child Health, London, UK "This textbook - a pioneer in this field - offers a useful and actual overview on pharmacogenetic testing in psychiatry and is especially dedicated to clinicians and practicing psychiatrists rather than scientists working in the field of pharmacogenomics."--Julia Kirchheiner, MD, Professor of Clinical Pharmacology, University of Ulm, Institute of Pharmacology of Natural Products & Clinical Pharmacology, Ulm, Germany "This remarkable volume should be read by all those who regularly prescribe psychotropic medication and more generally by those interested in how rapid scientific advances in molecular genomics and in the study of psychopathology together have led to major new resources for the treatment of mental illness. Dr. Mrazek's text is the first to comprehensively address psychiatric pharmacogenomics. The book is superbly written. This book is a rare combination of superb scientific writing, thoughtful clinical reflection, and profound understanding of this rapidly advancing field and should be read by all those concerned about the effects of mental illness in families. --William R. Beardslee, MD, Director, Baer Prevention Initiatives and Chairman Emeritus, Department of Psychiatry, Children's Hospital Boston, Gardner/Monks Professor of Child Psychiatry, Harvard Medical School, Boston, MA "This is an exciting book on the use of genetic testing for predicting adverse effects of, as well as response to, psychopharmacologic agents. The author, a pioneer in pharmacogenomics, has written an extremely informative book for clinicians and researchers. It is a very welcome addition to the psychiatric literature...This is a superb book on a very useful topic in clinical psychiatry. All psychiatrists need to be versed in the wisdom this book provides. " --Doody's 2010 PROSE Award Honorable Mention recipient, Biological Sciences "It would quite useful as a reference text to be utilized when a patient presents with a history of side effects from low doses of medications or nonresponse to medication. I hope that Dr Mrazek will have some mechanism to provide updates as this field advances." -- Psychiatrist.com, "Psychiatric Pharmacogenomics, authored by David A. Mrazek, M.D., F.R.C. Psych., is the most authoritative book in the field of psychiatric genetics produced in the XXI Century. This text is not only an ideal tool for the busy clinician, but also offers the knowledge required by educators and investigators in the field of psychiatry pharmacogenomics at large".--Pedro Ruiz, MD, President, American Psychiatric Association (2006-2007); President Elect, WorldPsychiatric Association (2008-2011); and Professor of Psychiatry and Vice Chair for Education, Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, Texas"In his book on psychiatric pharmacogenomics, Dr. Mrazek distils his scientific wisdom with clinical insights, to produce a unique guide to the theory and practice of this nascent specialty. He takes us on a journey of discovery, from the initial perplexing observations that different patients respond differently to the same medication in the same dose, to our understanding that this differential responsiveness could often be due to common geneticvariation...This is a timely and hugely important book, pulling together the strands of psychiatric pharmacogenomics in an accessible way that provides clear guidance to clinicians, and is also an invaluable reviewof contemporaneous research for scientists working in the field."--David H. Skuse, MD, Behavioral and Brain Sciences Unit, Institute of Child Health, London, UK"This textbook - a pioneer in this field - offers a useful and actual overview on pharmacogenetic testing in psychiatry and is especially dedicated to clinicians and practicing psychiatrists rather than scientists working in the field of pharmacogenomics."--Julia Kirchheiner, MD, Professor of Clinical Pharmacology, University of Ulm, Institute of Pharmacology of Natural Products & Clinical Pharmacology, Ulm, Germany"This remarkable volume should be read by all those who regularly prescribe psychotropic medication and more generally by those interested in how rapid scientific advances in molecular genomics and in the study of psychopathology together have led to major new resources for the treatment of mental illness. Dr. Mrazek's text is the first to comprehensively address psychiatric pharmacogenomics. The book is superbly written. This book is a rare combination ofsuperb scientific writing, thoughtful clinical reflection, and profound understanding of this rapidly advancing field and should be read by all those concerned about the effects of mental illness infamilies. --William R. Beardslee, MD, Director, Baer Prevention Initiatives and Chairman Emeritus, Department of Psychiatry, Children's Hospital Boston, Gardner/Monks Professor of Child Psychiatry, Harvard Medical School, Boston, MA"This is an exciting book on the use of genetic testing for predicting adverse effects of, as well as response to, psychopharmacologic agents. The author, a pioneer in pharmacogenomics, has written an extremely informative book for clinicians and researchers. It is a very welcome addition to the psychiatric literature...This is a superb book on a very useful topic in clinical psychiatry. All psychiatrists need to be versed in the wisdom this book provides. "--Doody's2010 PROSE Award Honorable Mention recipient, Biological Sciences"It would quite useful as a reference text to be utilized when a patient presents with a history of side effects from low doses of medications or nonresponse to medication. I hope that Dr Mrazek will have some mechanism to provide updates as this field advances." -- Psychiatrist.com, "Psychiatric Pharmacogenomics, authored by David A. Mrazek, M.D., F.R.C. Psych., is the most authoritative book in the field of psychiatric genetics produced in the XXI Century. This text is not only an ideal tool for the busy clinician, but also offers the knowledge required by educators and investigators in the field of psychiatry pharmacogenomics at large".--Pedro Ruiz, MD, President, American Psychiatric Association (2006-2007); President Elect, World Psychiatric Association (2008-2011); and Professor of Psychiatry and Vice Chair for Education, Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, Texas "In his book on psychiatric pharmacogenomics, Dr. Mrazek distils his scientific wisdom with clinical insights, to produce a unique guide to the theory and practice of this nascent specialty. He takes us on a journey of discovery, from the initial perplexing observations that different patients respond differently to the same medication in the same dose, to our understanding that this differential responsiveness could often be due to common genetic variation...This is a timely and hugely important book, pulling together the strands of psychiatric pharmacogenomics in an accessible way that provides clear guidance to clinicians, and is also an invaluable review of contemporaneous research for scientists working in the field."--David H. Skuse, MD, Behavioral and Brain Sciences Unit, Institute of Child Health, London, UK "This textbook - a pioneer in this field - offers a useful and actual overview on pharmacogenetic testing in psychiatry and is especially dedicated to clinicians and practicing psychiatrists rather than scientists working in the field of pharmacogenomics."--Julia Kirchheiner, MD, Professor of Clinical Pharmacology, University of Ulm, Institute of Pharmacology of Natural Products & Clinical Pharmacology, Ulm, Germany "This remarkable volume should be read by all those who regularly prescribe psychotropic medication and more generally by those interested in how rapid scientific advances in molecular genomics and in the study of psychopathology together have led to major new resources for the treatment of mental illness. Dr. Mrazek's text is the first to comprehensively address psychiatric pharmacogenomics. The book is superbly written. This book is a rare combination of superb scientific writing, thoughtful clinical reflection, and profound understanding of this rapidly advancing field and should be read by all those concerned about the effects of mental illness in families. --William R. Beardslee, MD, Director, Baer Prevention Initiatives and Chairman Emeritus, Department of Psychiatry, Children's Hospital Boston, Gardner/Monks Professor of Child Psychiatry, Harvard Medical School, Boston, MA "This is an exciting book on the use of genetic testing for predicting adverse effects of, as well as response to, psychopharmacologic agents. The author, a pioneer in pharmacogenomics, has written an extremely informative book for clinicians and researchers. It is a very welcome addition to the psychiatric literature...This is a superb book on a very useful topic in clinical psychiatry. All psychiatrists need to be versed in the wisdom this book provides. " --Doody's
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
615/.788
Table Of Content
I. Basic FoundationsIntroduction1. The Language of Molecular Genetics2. The Fourteen Genes3. The Problem and the SolutionII. The Drug Metabolizing Enzyme Genes4. The Cytochrome P450 2D6 Gene5. The Cytochrome P450 2C19 Gene6. The Cytochrome P450 2C9 Gene7. The Cytochrome P450 1A2 GeneIII. A Gene Associated with the Metabolism of Neurotransmitters8. The Catechol-O-Methyltransferase GeneIV. The Neurotransmitter Transporter Genes9. The SLC6A2 Norepinephrine Transporter Gene10. The SLC6A3 Dopamine Transporter Gene11. The SLC6A4 Serotonin Transporter GeneV. The Serotonin Receptor Genes12. The Serotonin 1A Receptor Gene13. The Serotonin 2A Receptor Gene14. The Serotonin 2C Receptor GeneVI. The Dopamine Receptor Genes15. The Dopamine D2 Receptor Gene16. The Dopamine D3 Receptor Gene17. The Dopamine D4 Receptor GeneVII. Clinical Considerations18. The Clinical Utility of Psychiatric Pharmacogenomic Testing19. Ethical Issues to Consider When Using Pharmacogenomic Testing in Psychiatric Practice20. Future Development of Psychiatric Pharmacogenomic TestingGlossary of Genetic and Pharmacogenomic TermsGeneric and Brand Names of Pharmacogenomically Relevant DrugsIndex
Synopsis
Psychiatric Pharmacogenomics is the first practical guide to instruct psychiatrists and other clinicians on how to more effectively and safely prescribe psychotropic medications using pharmacogenomic testing. The rationale for pharmacogenomic testing is discussed in detail as it pertains to individual gene variability. Technical information about the nature and extent of genetic variability is included in special sections of each chapter. The most unique feature of the book is the inclusion of a series of clinical vignettes that illustrate the clinical usefulness of pharmacogenomic testing., Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication. The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients. The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes. The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing., Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication.The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients. The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes. The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing.
LC Classification Number
RM315.M73 2010

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