Regulation of Gene Expression by Gary H. Perdew Hardcover Medical Textbook Book

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Zuletzt aktualisiert am 22. Aug. 2024 03:14:18 MESZAlle Änderungen ansehenAlle Änderungen ansehen

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Product Type
Textbook
Features
Does Not Apply
ISBN
9781588292650
Kategorie

Über dieses Produkt

Product Identifiers

Publisher
Humana Press
ISBN-10
1588292657
ISBN-13
9781588292650
eBay Product ID (ePID)
103092486

Product Key Features

Number of Pages
IX, 333 Pages
Publication Name
Regulation of Gene Expression : Molecular Mechanisms
Language
English
Publication Year
2006
Subject
Life Sciences / Biochemistry, Life Sciences / Genetics & Genomics, Genetics, Pharmacology
Type
Textbook
Subject Area
Science, Medical
Author
Jeffrey M. Peters, Jack P. Vanden Heuvel, Gary H. Perdew
Format
Hardcover

Dimensions

Item Weight
23.7 Oz
Item Length
9.3 in
Item Width
6.1 in

Additional Product Features

Intended Audience
Scholarly & Professional
LCCN
2006-020090
Reviews
From the reviews: "The book is aimed at graduate students, filling a gap between more general text books ... and laboratory manuals (e.g. the Current Protocols series). ... Helpful notes and key references are given in the margins throughout the text. ... overall 'Regulation of Gene Expression: Molecular Mechanisms' would certainly be of use to life sciences undergraduates, it would also be a useful reference work for a Molecular Toxicology laboratory." (James Sidaway, British Toxicology Society Newsletter, Summer, 2007), From the reviews:"The book is aimed at graduate students, filling a gap between more general text books … and laboratory manuals (e.g. the Current Protocols series). … Helpful notes and key references are given in the margins throughout the text. … overall 'Regulation of Gene Expression: Molecular Mechanisms' would certainly be of use to life sciences undergraduates, it would also be a useful reference work for a Molecular Toxicology laboratory." (James Sidaway, British Toxicology Society Newsletter, Summer, 2007)
Dewey Edition
22
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
572.8/65
Table Of Content
Gene Expression Control At The Mrna Level.- Overview.- Messenger RNA Accumulation.- Transcript Profiling.- Transcriptional Regulation of Gene Expression.- Posttranscriptional Processing of Messenger RNA.- Regulation Of Protein Levels And Transcription Factor Function.- Overview.- Protein Synthesis and Turnover.- Proteomics.- Determination of Protein-Protein Interactions and the Motifs That Mediate Them.- Posttranslational Modifications.- Dissection of Signaling Pathways.- Use Of Transgenic And Knockout Mice To Study Gene Regulation.- Overview.- Production of Transgenic Animals.- Knockout Animals.- Isolation of Cells and Cell Lines From Transgenic and Knockout Animals.
Synopsis
The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select "Courses. " The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell., The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http: //moltox. cas. psu. edu and select "Courses. " The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.
LC Classification Number
QD415-436

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