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Eine Einführung in die Systembiologie
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- ISBN
- 9781584886426
Über dieses Produkt
Product Identifiers
Publisher
CRC Press LLC
ISBN-10
1584886420
ISBN-13
9781584886426
eBay Product ID (ePID)
50578418
Product Key Features
Number of Pages
320 Pages
Publication Name
Introduction to Systems Biology : Design Principles of Biological Circuits
Language
English
Subject
Biotechnology, Life Sciences / Biology, Applied, Physics / General
Publication Year
2006
Type
Textbook
Subject Area
Mathematics, Science
Series
Chapman and Hall/Crc Mathematical and Computational Biology Ser.
Format
Perfect / Trade Paperback
Dimensions
Item Height
0.6 in
Item Weight
24.1 Oz
Item Length
10 in
Item Width
7 in
Additional Product Features
Intended Audience
College Audience
LCCN
2005-056902
TitleLeading
An
Reviews
"[This text deserves] serious attention from any quantitative scientist or physicist who hopes to learn about modern biology. [It is] well written. … Alon's book is the better place for physicists to start. It assumes no prior knowledge of or even interest in biology. Yet right from chapter 1, the author succeeds in explaining in an intellectually exciting way what the cell does and what degrees of freedom enable it to function. … The book proceeds with detailed discussions of some of the key network motifs, circuit-element designs … [and] focuses on concrete examples such as chemotaxis and developmental pattern formation. … He draws the detailed strands together into an appealing and inspiring overview of biology. … One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. … Alon's book should become a standard part of the training of graduate students in biological physics… ." -Nigel Goldenfeld, University of Illinois at Urbana-Champaign,Physics Today, June 2007 "…a superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. … Alon investigates networks at a higher level, including genomic regulatory networks. He does an excellent job of explaining and motivating a useful toolbox of engineering models and methods using network-based controls. … will be a valuable and non-overlapping addition to a systems-biology curriculum." -Eric Werner, Department of Physiology, Anatomy and Genetics, University of Oxford, Nature,Vol. 446, No. 29, March 2007 "I read Uri Alon's elegant book almost without stopping for breath. He perceives and explains so many simple regularities, so clearly, that the novice reading this book can move on immediately to research literature, armed with a grasp of the many connections between diverse phenomena." -Philip Nelson, Professor of Physics, University of Pennsylvania, Philadelphia, USA "… Beyond simply recounting recent results, Alon boldly articulates the basic principles underlying biological circuitry at different levels and shows how powerful they can be in understanding the complexity of living cells. For anyone who wants to understand how a living cell works, but thought they never would, this book is essential." -Michael B. Elowitz, California Institute of Technology, Pasadena, USA "Uri Alon offers a highly original perspective on systems biology, emphasizing the function of certain simple networks that appear as ubiquitous building blocks of living matter. The quest for simplicity - without losing contact with complex reality - is the only way to uncover the principles organizing biological systems. Alon writes with uncommon lucidity…" -Boris Shraiman, University of California, Santa Barbara, USA "This is a remarkable book that introduces not only a field but a way of thinking. Uri Alon describes in an elegant, simple way how principles such as stability, robustness and optimal design can be used to analyze and understand the evolution and behavior of living organisms. Alon's clear intuitive language and helpful examples offer - even to a mathematically naive reader - deep mathematical insights into biology. The community has been waiting for this book; it was worth the wait." -Galit Lahav, Harvard Medical School, Boston, Massachusetts, USA, "[This text deserves] serious attention from any quantitative scientist or physicist who hopes to learn about modern biology. [It is] well written. ... Alon's book is the better place for physicists to start. It assumes no prior knowledge of or even interest in biology. Yet right from chapter 1, the author succeeds in explaining in an intellectually exciting way what the cell does and what degrees of freedom enable it to function. ... The book proceeds with detailed discussions of some of the key network motifs, circuit-element designs ... [and] focuses on concrete examples such as chemotaxis and developmental pattern formation. ... He draws the detailed strands together into an appealing and inspiring overview of biology. ... One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. ... Alon's book should become a standard part of the training of graduate students in biological physics... ." --Nigel Goldenfeld, University of Illinois at Urbana-Champaign,Physics Today, June 2007 "...a superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. ... Alon investigates networks at a higher level, including genomic regulatory networks. He does an excellent job of explaining and motivating a useful toolbox of engineering models and methods using network-based controls. ... will be a valuable and non-overlapping addition to a systems-biology curriculum." --Eric Werner, Department of Physiology, Anatomy and Genetics, University of Oxford, Nature,Vol. 446, No. 29, March 2007 "I read Uri Alon's elegant book almost without stopping for breath. He perceives and explains so many simple regularities, so clearly, that the novice reading this book can move on immediately to research literature, armed with a grasp of the many connections between diverse phenomena." --Philip Nelson, Professor of Physics, University of Pennsylvania, Philadelphia, USA "... Beyond simply recounting recent results, Alon boldly articulates the basic principles underlying biological circuitry at different levels and shows how powerful they can be in understanding the complexity of living cells. For anyone who wants to understand how a living cell works, but thought they never would, this book is essential." --Michael B. Elowitz, California Institute of Technology, Pasadena, USA "Uri Alon offers a highly original perspective on systems biology, emphasizing the function of certain simple networks that appear as ubiquitous building blocks of living matter. The quest for simplicity -- without losing contact with complex reality -- is the only way to uncover the principles organizing biological systems. Alon writes with uncommon lucidity..." --Boris Shraiman, University of California, Santa Barbara, USA "This is a remarkable book that introduces not only a field but a way of thinking. Uri Alon describes in an elegant, simple way how principles such as stability, robustness and optimal design can be used to analyze and understand the evolution and behavior of living organisms. Alon's clear intuitive language and helpful examples offer -- even to a mathematically naive reader -- deep mathematical insights into biology. The community has been waiting for this book; it was worth the wait." --Galit Lahav, Harvard Medical School, Boston, Massachusetts, USA, "[This text deserves] serious attention from any quantitative scientist or physicist who hopes to learn about modern biology. [It is] well written. ... Alon's book is the better place for physicists to start. It assumes no prior knowledge of or even interest in biology. Yet right from chapter 1, the author succeeds in explaining in an intellectually exciting way what the cell does and what degrees of freedom enable it to function. ... The book proceeds with detailed discussions of some of the key network motifs, circuit-element designs ... [and] focuses on concrete examples such as chemotaxis and developmental pattern formation. ... He draws the detailed strands together into an appealing and inspiring overview of biology. ... One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. ... Alon's book should become a standard part of the training of graduate students in biological physics... ." --Nigel Goldenfeld, University of Illinois at Urbana-Champaign, Physics Today, June 2007 "...a superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. ... Alon investigates networks at a higher level, including genomic regulatory networks. He does an excellent job of explaining and motivating a useful toolbox of engineering models and methods using network-based controls. ... will be a valuable and non-overlapping addition to a systems-biology curriculum." --Eric Werner, Department of Physiology, Anatomy and Genetics, University of Oxford, Nature, Vol. 446, No. 29, March 2007 "I read Uri Alon's elegant book almost without stopping for breath. He perceives and explains so many simple regularities, so clearly, that the novice reading this book can move on immediately to research literature, armed with a grasp of the many connections between diverse phenomena." --Philip Nelson, Professor of Physics, University of Pennsylvania, Philadelphia, USA "... Beyond simply recounting recent results, Alon boldly articulates the basic principles underlying biological circuitry at different levels and shows how powerful they can be in understanding the complexity of living cells. For anyone who wants to understand how a living cell works, but thought they never would, this book is essential." --Michael B. Elowitz, California Institute of Technology, Pasadena, USA "Uri Alon offers a highly original perspective on systems biology, emphasizing the function of certain simple networks that appear as ubiquitous building blocks of living matter. The quest for simplicity -- without losing contact with complex reality -- is the only way to uncover the principles organizing biological systems. Alon writes with uncommon lucidity..." --Boris Shraiman, University of California, Santa Barbara, USA "This is a remarkable book that introduces not only a field but a way of thinking. Uri Alon describes in an elegant, simple way how principles such as stability, robustness and optimal design can be used to analyze and understand the evolution and behavior of living organisms. Alon's clear intuitive language and helpful examples offer -- even to a mathematically naive reader -- deep mathematical insights into biology. The community has been waiting for this book; it was worth the wait." --Galit Lahav, Harvard Medical School, Boston, Massachusetts, USA, "[This text deserves] serious attention from any quantitative scientist or physicist who hopes to learn about modern biology. [It is] well written. Alon "s book is the better place for physicists to start. It assumes no prior knowledge of or even interest in biology. Yet right from chapter 1, the author succeeds in explaining in an intellectually exciting way what the cell does and what degrees of freedom enable it to function. The book proceeds with detailed discussions of some of the key network motifs, circuit-element designs [and] focuses on concrete examples such as chemotaxis and developmental pattern formation. He draws the detailed strands together into an appealing and inspiring overview of biology. One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. Alon "s book should become a standard part of the training of graduate students in biological physics ." "Nigel Goldenfeld, University of Illinois at Urbana-Champaign,Physics Today, June 2007 " a superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. Alon investigates networks at a higher level, including genomic regulatory networks. He does an excellent job of explaining and motivating a useful toolbox of engineering models and methods using network-based controls. will be a valuable and non-overlapping addition to a systems-biology curriculum." "Eric Werner, Department of Physiology, Anatomy and Genetics, University of Oxford, Nature,Vol. 446, No. 29, March 2007 "I read Uri Alon "s elegant book almost without stopping for breath. He perceives and explains so many simple regularities, so clearly, that the novice reading this book can move on immediately to research literature, armed with a grasp of the many connections between diverse phenomena." "Philip Nelson, Professor of Physics, University of Pennsylvania, Philadelphia, USA " Beyond simply recounting recent results, Alon boldly articulates the basic principles underlying biological circuitry at different levels and shows how powerful they can be in understanding the complexity of living cells. For anyone who wants to understand how a living cell works, but thought they never would, this book is essential." "Michael B. Elowitz, California Institute of Technology, Pasadena, USA "Uri Alon offers a highly original perspective on systems biology, emphasizing the function of certain simple networks that appear as ubiquitous building blocks of living matter. The quest for simplicity " without losing contact with complex reality " is the only way to uncover the principles organizing biological systems. Alon writes with uncommon lucidity " "Boris Shraiman, University of California, Santa Barbara, USA "This is a remarkable book that introduces not only a field but a way of thinking. Uri Alon describes in an elegant, simple way how principles such as stability, robustness and optimal design can be used to analyze and understand the evolution and behavior of living organisms. Alon "s clear intuitive language and helpful examples offer " even to a mathematically naive reader " deep mathematical insights into biology. The community has been waiting for this book; it was worth the wait." "Galit Lahav, Harvard Medical School, Boston, Massachusetts, USA, "[This text deserves] serious attention from any quantitative scientist or physicist who hopes to learn about modern biology. [It is] well written. e Alone(tm)s book is the better place for physicists to start. It assumes no prior knowledge of or even interest in biology. Yet right from chapter 1, the author succeeds in explaining in an intellectually exciting way what the cell does and what degrees of freedom enable it to function. e The book proceeds with detailed discussions of some of the key network motifs, circuit-element designs e [and] focuses on concrete examples such as chemotaxis and developmental pattern formation. e He draws the detailed strands together into an appealing and inspiring overview of biology. e One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. e Alone(tm)s book should become a standard part of the training of graduate students in biological physicse ." e"Nigel Goldenfeld, University of Illinois at Urbana-Champaign, Physics Today, June 2007 "ea superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. e Alon investigates networks at a higher level, including genomic regulatory networks. He does an excellent job of explaining and motivating a useful toolbox of engineering models and methods using network-based controls. e will be a valuable and non-overlapping addition to a systems-biology curriculum." e"Eric Werner, Department of Physiology, Anatomy and Genetics, University of Oxford, Nature, Vol. 446, No. 29, March 2007 "I read Uri Alone(tm)s elegant book almost without stopping for breath. He perceives and explains so many simple regularities, so clearly, that the novice reading this book can move on immediately to research literature, armed with a grasp of the many connections between diverse phenomena." e"Philip Nelson, Professor of Physics, University of Pennsylvania, Philadelphia, USA "e Beyond simply recounting recent results, Alon boldly articulates the basic principles underlying biological circuitry at different levels and shows how powerful they can be in understanding the complexity of living cells. For anyone who wants to understand how a living cell works, but thought they never would, this book is essential." e"Michael B. Elowitz, California Institute of Technology, Pasadena, USA "Uri Alon offers a highly original perspective on systems biology, emphasizing the function of certain simple networks that appear as ubiquitous building blocks of living matter. The quest for simplicity e" without losing contact with complex reality e" is the only way to uncover the principles organizing biological systems. Alon writes with uncommon luciditye" e"Boris Shraiman, University of California, Santa Barbara, USA "This is a remarkable book that introduces not only a field but a way of thinking. Uri Alon describes in an elegant, simple way how principles such as stability, robustness and optimal design can be used to analyze and understand the evolution and behavior of living organisms. Alone(tm)s clear intuitive language and helpful examples offer e" even to a mathematically naive reader e" deep mathematical insights into biology. The community has been waiting for this book; it was worth the wait." e"Galit Lahav, Harvard Medical School, Boston, Massachusetts, USA, This is a remarkable book that introduces not only a field but a way of thinking. Uri Alon describes in an elegant, simple way how principles such as stability, robustness and optimal design can be used to analyze and understand the evolution and behavior of living organisms. Alon's clear intuitive language and helpful examples offer - even to a mathematically naive reader - deep mathematical insights into biology. The community has been waiting for this book; it was worth the wait.
Dewey Edition
22
Series Volume Number
Vol. 10
Illustrated
Yes
Dewey Decimal
570.285
Table Of Content
Transcription Networks, Basic Concepts. Auto-Regulation, a Network Motif. The Feedforward Loop Network Motif. Temporal Programs and the Global Structure of Transcription Networks. Network Motifs in Developmental, Signal-Transduction and Neuronal Networks. Robustness of Protein Circuits, the Example of Bacterial Chemotaxis. Robust Patterning in Development. Kinetic Proofreading. Optimal Gene Circuit Design. Rules for Gene Regulation Based on Error Minimization. Epilogue. Appendices. Glossary. Bibliography.
Synopsis
Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models., This book presents recently discovered design principles that govern the structure and behavior of biological networks such as gene circuits, highlighting simple, recurring circuit elements that make up the network. It provides a quantitative theory for which circuits are found in a given environment and a mathematical framework for understanding and even designing biological circuits. The book requires only basic mathematics and includes a review of the necessary background material. It fills a significant need for a textbook and introduction to the concepts, principles, and mathematical tools that will form the basis of future developments in the field., Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-st
LC Classification Number
QH324.2.A46 2006
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