Metabolomics Werkzeuge für die Entdeckung natürlicher Produkte: Methoden und Protokolle, Har...
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Artikelmerkmale
- Artikelzustand
- Book Title
- Metabolomics Tools for Natural Product Discovery : Methods and Pr
- ISBN
- 9781627035767
Über dieses Produkt
Product Identifiers
Publisher
Humana Press
ISBN-10
1627035761
ISBN-13
9781627035767
eBay Product ID (ePID)
166212159
Product Key Features
Number of Pages
X, 311 Pages
Language
English
Publication Name
Metabolomics Tools for Natural Product Discovery : Methods and Protocols
Publication Year
2013
Subject
Chemistry / Analytic, Endocrinology & Metabolism, Pharmacology
Type
Textbook
Subject Area
Science, Medical
Series
Methods in Molecular Biology Ser.
Format
Hardcover
Dimensions
Item Weight
265.9 Oz
Item Length
10 in
Item Width
7 in
Additional Product Features
Intended Audience
Scholarly & Professional
LCCN
2013-945168
Dewey Edition
23
Series Volume Number
1055
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
615.321
Table Of Content
Bryophytes: Liverworts, Mosses and Hornworts - Extraction and Isolation Procedures.- Plant Tissue Extraction for Metabolomics.- Detection of Polar Metabolites through the use of Gas Chromatography - Mass Spectrometry.- A Robust GC-MS Method for the Quantitation of Fatty Acids in Biological Systems.- A Workflow from Untargeted LC-MS Profiling to Targeted Natural Product Isolation.- Lipidomics -Extraction Protocols for Biological Matrices.- Metabolite Analysis of Biological Fluids and Tissues by Proton Nuclear Magnetic Resonance Spectroscopy.- NMR Spectroscopy: Structure Elucidation of Cycloelatenene A: A Natural Product Case Study.- NMR-Based Metabolomics: A Probe to Utilize Biodiversity.- Extraction Protocol for Non-Targeted NMR and LC-MS Metabolomics-Based Analysis of Hard Coral and their Algal Symbionts.- Determination of Absolute Configuration Using Single Crystal X-ray Diffraction.- Natural Product Chemistry in Action: The Synthesis of Melatonin Metabolites K1 and K2.- Discovery, Biosynthesis, and Rational Engineering of Novel Enterocin and WailupemycinPolyketide Analogues.- Bioassays for Anticancer Activities.- Screening for Anti-Diabetic Activities.- Screening for Antibacterial, Antifungal and Anti-Quorum Sensing Activity.- Metabolomics and Dereplication Strategies in Natural Products.- Bridging the Gap: Basic Metabolomics Methods for Natural Product Chemistry.- Strategies in Biomarker Discovery. Peak Annotation by MS and Targeted LC-MS Micro-Fractionation for de novo Structure Identification by Micro-NMR.- Statistical Analysis of Metabolomics Data.
Synopsis
Classical natural product chemistry is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. Therefore, it is worthwhile to summarize recent developments with current analytical platforms and highlight how metabolomics is being integrated into this classical field to dereplicate and profile natural product extracts. Metabolomics Tools for Natural Product Discoveries: Methods and Protocols aims to unite diverse and recently developed methodologies and protocols in order to identify bioactive secondary metabolites for the purpose of drug discovery. Some topics covered in this volume include applications for the extraction of selected natural products from less common sources such as bryophytes and hard corals, various biological assays, comprehensive applications and strategies for GC-MS, LC-MS, and NMR, as well as protocols and strategies for the structure elucidation of isolated natural products. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible Metabolomics Tools for Natural Product Discoveries: Methods and Protocols seeks to serve both professionals and research students with its well-honed methodologies for natural product isolation, biomarker discovery, dereplication, biological assays, and comprehensive metabolomic platforms available for high-throughputanalyses., 1. Bryophytes: Liverworts, Mosses and Hornworts - Extraction and Isolation Procedures Yoshinori Asakawa and Agnieszka Ludwiczuk 2. Plant Tissue Extraction for Metabolomics Ute Roessner and Daniel Anthony Dias 3. Detection of Polar Metabolites through the use of Gas Chromatography - Mass Spectrometry David P. De Souza 4. A Robust GC-MS Method for the Quantitation of Fatty Acids in Biological Systems Nirupama Samanmalie Jayasinghe and Daniel Anthony Dias 5. A Workflow from Untargeted LC-MS Profiling to Targeted Natural Product Isolation Damien L. Callahan and Candace E. Elliot 6. Lipidomics -Extraction Protocols for Biological Matrices Thusitha Wasntha Thilanka Rupasinghe 7. Metabolite Analysis of Biological Fluids and Tissues by Proton Nuclear Magnetic Resonance Spectroscopy John Robert Sheedy 8. NMR Spectroscopy: Structure Elucidation of Cycloelatenene A: A Natural Product Case Study Sylvia Urban and Daniel Anthony Dias 9. NMR-Based Metabolomics: A Probe to Utilize Biodiversity Lúcia P. Santos Pimenta, Hye Kyong Kim, Robert Verpoorte, and Young Hae Choi 10. Extraction Protocol for Non-Targeted NMR and LC-MS Metabolomics-Based Analysis of Hard Coral and their Algal Symbionts Benjamin R. Gordon, William Leggat, and Cherie Motti 11. Determination of Absolute Configuration Using Single Crystal X-ray Diffraction Abigail L. Albright and Jonathan M. White 12. Natural Product Chemistry in Action: The Synthesis of Melatonin Metabolites K1 and K2 Helmut M. Hügel and Oliver A.H. Jones 13. Discovery, Biosynthesis, and Rational Engineering of Novel Enterocin and Wailupemycin Polyketide Analogues John A. Kalaitziz 14. Bioassays for Anticancer Activities Janice McCauley, Ana Zivanovic, and D. Skropeta 15. Screening for Anti-Diabetic Activities Rima Caccetta and Hani Al Salami 16. Screening for Antibacterial, Antifungal and Anti-Quorum Sensing Activity Elisa J. Hayhoe and Enzo A. Palombo 17. Metabolomics and Dereplication Strategies in Natural Products Ahmed Fares Tawfike, Christina Viegelmann, and RuAngelie Edrada-Ebel 18. Bridging the Gap: Basic Metabolomics Methods for Natural Product Chemistry Oliver A.H. Jones and Helmut M. Hügel 19. Strategies in Biomarker Discovery. Peak Annotation by MS and Targeted LC-MS Micro-Fractionation for de novo Structure Identification by Micro-NMR Philippe J. Eugster, Gaëtan Glauser, and Jean-Luc Wolfender 20. Statistical Analysis of Metabolomics Data Alysha M. De Livera, Moshe Olshansky, and Terence P. Speed, This book presents methodologies for natural product isolation, biomarker discovery, dereplication, biological assays, and comprehensive metabolomic platforms available for high-throughput analyses. It features step-by-step, readily reproducible protocols., Classical natural product chemistry is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. Therefore, it is worthwhile to summarize recent developments with current analytical platforms and highlight how metabolomics is being integrated into this classical field to dereplicate and profile natural product extracts. Metabolomics Tools for Natural Product Discoveries: Methods and Protocols aims to unite diverse and recently developed methodologies and protocols in order to identify bioactive secondary metabolites for the purpose of drug discovery. Some topics covered in this volume include applications for the extraction of selected natural products from less common sources such as bryophytes and hard corals, various biological assays, comprehensive applications and strategies for GC-MS, LC-MS, and NMR, as well as protocols and strategies for the structure elucidation of isolated natural products. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible Metabolomics Tools for Natural Product Discoveries: Methods and Protocols seeks to serve both professionals and research students with its well-honed methodologies for natural product isolation, biomarker discovery, dereplication, biological assays, and comprehensive metabolomic platforms available for high-throughput analyses.
LC Classification Number
RM300-666
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- 1***n (278)- Bewertung vom Käufer.Letzte 6 MonateBestätigter KaufReceived the Tying Nymphs: Essential Flies and Techniques for the Top Patterns, Hardcover. The book is of high quality. I'm very happy with my purchase and will continue to order from this seller. This seller has the best communications that I have ever seen in a sell. The book is at a great value. The book was as described and in excellent condition. Shipping was very fast. The appearance of the book was excellent. The item was very well packaged. Again, I will continue buy from this sell.