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Bacterial Signal Transduction: Networks and Drug Targets
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eBay-Artikelnr.:395145304757
Artikelmerkmale
- Artikelzustand
- PublishedOn
- 2010-11-24
- Title
- Bacterial Signal Transduction: Networks and Drug Targets
- Artist
- Not Specified
- ISBN
- 9781441927033
Über dieses Produkt
Product Identifiers
Publisher
Springer New York
ISBN-10
1441927034
ISBN-13
9781441927033
eBay Product ID (ePID)
109316987
Product Key Features
Number of Pages
Xvii, 242 Pages
Publication Name
Bacterial Signal Transduction : Networks and Drug Targets
Language
English
Subject
Life Sciences / Molecular Biology, Life Sciences / Biochemistry, Research
Publication Year
2010
Type
Textbook
Subject Area
Science, Medical
Series
Advances in Experimental Medicine and Biology Ser.
Format
Trade Paperback
Dimensions
Item Weight
17.9 Oz
Item Length
9.3 in
Item Width
6.1 in
Additional Product Features
Intended Audience
Scholarly & Professional
Dewey Edition
22
Reviews
Aus den Rezensionen: "... Dieses Buch ... gibt einen vertiefenden Einblick in die Komplexität ausgewählter Histidinkinase/ Antwortregulator-Systeme ... Das Buch ist eine Zusammenstellung aktueller Übersichtsartikel zu einzelnen Systemen und liefert somit Wissenschaftlern, die an diesen Themen forschen, eine Fülle von Daten ..." (Kirsten Jung, in: BIOspektrum, 2009, Vol. 15, Issue 5, S. 581), Aus den Rezensionen:"... Dieses Buch … gibt einen vertiefenden Einblick in die Komplexität ausgewählter Histidinkinase/ Antwortregulator-Systeme ... Das Buch ist eine Zusammenstellung aktueller Übersichtsartikel zu einzelnen Systemen und liefert somit Wissenschaftlern, die an diesen Themen forschen, eine Fülle von Daten ..." (Kirsten Jung, in: BIOspektrum, 2009, Vol. 15, Issue 5, S. 581), Aus den Rezensionen:"... Dieses Buch gibt einen vertiefenden Einblick in die Komplexit t ausgew hlter Histidinkinase/ Antwortregulator-Systeme ... Das Buch ist eine Zusammenstellung aktueller Sbersichtsartikel zu einzelnen Systemen und liefert somit Wissenschaftlern, die an diesen Themen forschen, eine F lle von Daten ..." (Kirsten Jung, in: BIOspektrum, 2009, Vol. 15, Issue 5, S. 581), Aus den Rezensionen: "... Dieses Buch ... gibt einen vertiefenden Einblick in die Komplexitt ausgewhlter Histidinkinase/ Antwortregulator-Systeme ... Das Buch ist eine Zusammenstellung aktueller bersichtsartikel zu einzelnen Systemen und liefert somit Wissenschaftlern, die an diesen Themen forschen, eine Flle von Daten ..." (Kirsten Jung, in: BIOspektrum, 2009, Vol. 15, Issue 5, S. 581)
Series Volume Number
631
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
571.7/4
Table Of Content
to Bacterial Signal Transduction Networks.- The PhoQ/PhoP Regulatory Network of Salmonella enterica.- Structural Basis of the Signal Transduction in the Two-Component System.- The Two-Component Network and the General Stress Sigma Factor RpoS (?S) in Escherichia coli.- Small RNAs Controlled by Two-Component Systems.- Two-Component Signaling and Gram Negative Envelope Stress Response Systems.- Dual Regulation with Ser/Thr Kinase Cascade and a His/Asp TCS in Myxococcus xanthus.- Two-Component Signaling Systems and Cell Cycle Control in Caulobacter crescentus.- RegB/RegA, A Global Redox-Responding Two-Component System.- The BvgS/BvgA Phosphorelay System of Pathogenic Bordetellae.- Capturing the VirA/VirG TCS of Agrobacterium tumefaciens.- Quorum Sensing and Biofilm Formation by Streptococcus mutans.- The Roles of Two-Component Systems in Virulence of Pathogenic Escherichia coli and Shigella spp..- Vancomycin Resistance VanS/VanR Two-Component Systems.- Tearing Down the Wall: Peptidoglycan Metabolism and the WalK/WalR (YycG/YycF) Essential Two-Component System.- Inhibitors Targeting Two-Component Signal Transduction.
Synopsis
A decade has passed since Drs. Hoch and Silhavy edited their comprehensive work entitled Two-Component Signal Transduction. This fascinating book encour aged many microbiologists and students to enter the new worldofsignal transduction in microbiology. In 2003, Dr. Inouye edited Histidine Kinase in Signal Transduc tion, which focused on histidine kinases and presented the wealth ofinformation accumulated on this protein family. Bacteria usually possess a numberofTwo-Component Systems (TCSs), rang ing from a few to over 100. InE. coli, 29 histidine kinases, 32 response regulators, and 1histidine-containing phosphor transmitter (HPt) domain have been found by analyses ofthe K-12 genome. Several examples ofin vitro and in vivo cross-talks and signal transductioncascadesbetweenTCSs inE. coli have beenreported,which suggests the existence ofa TCS network (Chapter 1). Interactions among different TCSs enable one system to respond to multiple signals, which is important for bacteria to minutely adjust themselves to complex environmental changes. Such interactions are found or predicted in various bacteria in this book. Many ofthese interactions might be connected by small proteins such as B1500(Chapter 1)and PmrD (Chapter2). More examplesofsuch proteins should be identified in the near future in order to fill-in the missing parts ofthe bacterial signal transduction network, a new paradigm that is increasingly recognized as the signal transduction pathway in bacterial cells. For drug discovery, this pathway is consideredas important as the signal transductionpathway in animal cells (Chapters 15 and 16)., A decade has passed since Drs. Hoch and Silhavy edited their comprehensive work entitled Two-Component Signal Transduction. This fascinating book encour- aged many microbiologists and students to enter the new worldofsignal transduction in microbiology. In 2003, Dr. Inouye edited Histidine Kinase in Signal Transduc- tion, which focused on histidine kinases and presented the wealth ofinformation accumulated on this protein family. Bacteria usually possess a numberofTwo-Component Systems (TCSs), rang- ing from a few to over 100. InE. coli, 29 histidine kinases, 32 response regulators, and 1histidine-containing phosphor transmitter (HPt) domain have been found by analyses ofthe K-12 genome. Several examples ofin vitro and in vivo cross-talks and signal transductioncascadesbetweenTCSs inE. coli have beenreported, which suggests the existence ofa TCS network (Chapter 1). Interactions among different TCSs enable one system to respond to multiple signals, which is important for bacteria to minutely adjust themselves to complex environmental changes. Such interactions are found or predicted in various bacteria in this book. Many ofthese interactions might be connected by small proteins such as B1500(Chapter 1)and PmrD (Chapter2). More examplesofsuch proteins should be identified in the near future in order to fill-in the missing parts ofthe bacterial signal transduction network, a new paradigm that is increasingly recognized as the signal transduction pathway in bacterial cells. For drug discovery, this pathway is consideredas important as the signal transductionpathway in animal cells (Chapters 15 and 16)., This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been unearthed.
LC Classification Number
R850.A1-854
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