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Systemmedizin (Chapman & Hall/CRC - Taschenbuch, von Alon Uri - Neu h
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eBay-Artikelnr.:405185229932
Artikelmerkmale
- Artikelzustand
- Book Title
- Systems Medicine (Chapman & Hall/CRC Computational Biology Series
- ISBN
- 9781032411859
Über dieses Produkt
Product Identifiers
Publisher
CRC Press LLC
ISBN-10
1032411856
ISBN-13
9781032411859
eBay Product ID (ePID)
10061621446
Product Key Features
Number of Pages
288 Pages
Language
English
Publication Name
Systems Medicine : Physiological Circuits and the Dynamics of Disease
Subject
Programming / Games, Computer Science, General, Life Sciences / Biology
Publication Year
2023
Type
Textbook
Subject Area
Computers, Science
Series
Chapman and Hall/Crc Computational Biology Ser.
Format
Trade Paperback
Dimensions
Item Length
10 in
Item Width
7 in
Additional Product Features
Intended Audience
Trade
LCCN
2023-014141
Reviews
"This book will be as influential and transformative as Alon's Systems Biology. Its quantitative approach provides new insight into the mechanisms that underline common diseases. It should be of interest to students and researchers in medicine, biology, and engineering." --Liqun Luo, Department of Biology, Stanford University, USA Praise for An Introduction to Systems Biology: Design Principles of Biological Circuits "[This text deserves] serious attention from any quantitative scientist or physicist who hopes to learn about modern biology. ... the author succeeds in explaining in an intellectually exciting way what the cell does and what degrees of freedom enable it to function. ... He draws the detailed strands together into an appealing and inspiring overview of biology. ... Alon's book should become a standard part of the training of graduate students in biological physics... ." --Nigel Goldenfeld, University of Illinois at Urbana-Champaign, Physics Today, June 2007 "...a superb, beautifully written and organized work that takes an engineering approach to systems biology. ... He does an excellent job of explaining and motivating a useful toolbox of engineering models and methods using network-based controls. ... a valuable and non-overlapping addition to a systems-biology curriculum." --Eric Werner, University of Oxford, Nature, Vol. 446, No. 29, March 2007 "I read Uri Alon's elegant book almost without stopping for breath. He perceives and explains so many simple regularities, so clearly, that the novice reading this book can move on immediately to research literature, armed with a grasp of the many connections between diverse phenomena." --Philip Nelson, University of Pennsylvania, Philadelphia, USA "... Beyond simply recounting recent results, Alon boldly articulates the basic principles underlying biological circuitry at different levels and shows how powerful they can be in understanding the complexity of living cells. For anyone who wants to understand how a living cell works, but thought they never would, this book is essential." --Michael B. Elowitz, California Institute of Technology, Pasadena, USA "Uri Alon offers a highly original perspective on systems biology, emphasizing the function of certain simple networks that appear as ubiquitous building blocks of living matter. ..." --Boris Shraiman, University of California, Santa Barbara, USA "This is a remarkable book that introduces not only a field but a way of thinking. Uri Alon describes in an elegant, simple way how principles such as stability, robustness and optimal design can be used to analyze and understand the evolution and behavior of living organisms. Alon's clear intuitive language and helpful examples offer -- even to a mathematically naive reader -- deep mathematical insights into biology. The community has been waiting for this book; it was worth the wait." --Galit Lahav, Harvard Medical School, Boston, Massachusetts, USA "Systems biology is based on the idea that engineered and evolved systems share common principles. Here, Alon (Weizmann Inst. of Science, Rehovot) elucidates three of the major principles... This book is a compendium of many different experiments. Together, they show that biological systems do obey these design principles." --P. Cull, Oregon State University, CHOICE connect (57:5, Jan 2020) "A very good book. Very well written, everything is clearly illustrated and presented. It makes a tough subject easy to follow." --Radu Angelescu, Senior Programmer at Ubisoft "Alon's book is the ideal counterargument to the idea that organisms are inherently human-opaque: it directly demonstrates the human-understandable structures which comprise real biological systems." --LessWrong.com
Dewey Edition
23
Illustrated
Yes
Dewey Decimal
570.285
Table Of Content
Introduction. 1. The Insulin-Glucose Circuit. 2. Dynamical Compensation, Mutant Resistance, and Type-2 Diabetes. 2.5. Three Laws of Physiology. 3.The Stress Hormone Axis as a Two-Gland Oscillator. 3.5 The Thyroid and its Discontents. 4. Autoimmune Diseases as a Fragility of Mutant Surveillance. 5. Inflammation and Fibrosis as a Bistable System. 6. Basic Facts of Aging. 7. Aging and Saturated Repair. 8. Age-Related Diseases. 9. Periodic Table of Diseases. 10. Epilogue: Simplicity in Systems Medicine.
Synopsis
Systems Medicine introduces the topic of physiological circuits, in which cells and organs communicate. It is written in a very accessible style, suitable for anyone with a background in biology, engineering, physics, math, engineering, computer science, chemistry or other subjects., Systems Medicine: Physiological Circuits and the Dynamics of Disease introduces the topic of physiological circuits, in which cells and organs communicate with each other. Rather than circuits inside a cell, it discusses circuits between cells. This is the level relevant to the most common and deadly diseases that currently plague humanity. The goal is to start from basic principles or 'laws' and derive why physiology is built the way it is, and why certain diseases happen while others don't. By the end of the book you will be able to use simple but powerful mathematical models to describe physiological circuits. The models are powerful because they turn details into useful understanding and new ways to think about treating diseases. We will understand the fundamental causes of some of the most mysterious diseases: diabetes, autoimmune diseases, and age-related diseases such as lung fibrosis and cancer. The trajectory begins with basic principles. From these are derived circuits and their fragility to disease. The book explores (i) hormone circuits, (ii) immune circuits, and (iii) aging and age-related disease, and culminates in a periodic table of diseases. It is written in a very accessible style, suitable for anyone with a background in biology, engineering, physics, math, engineering, computer science, chemistry or other subjects.
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