Über dieses Produkt

Product Identifiers

PublisherCRC Press LLC

ISBN-101420094971

ISBN-139781420094978

eBay Product ID (ePID)109256166

Product Key Features

Number of Pages510 Pages

Publication NameQuantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs

LanguageEnglish

Publication Year2009

SubjectSpectroscopy & Spectrum Analysis, Toxicology, Pharmacology, Forensic Science, Chemistry / General

TypeTextbook

AuthorSheng-MENG Wang, Dennis V. Canfield, Ray H. Liu

Subject AreaLaw, Science, Medical

FormatHardcover

Dimensions

Item Height1.3 in

Item Weight48.9 Oz

Item Length11.3 in

Item Width8.7 in

Additional Product Features

Intended AudienceScholarly & Professional

LCCN2009-026283

ReviewsThe information presented in this book is definitely of value to any laboratory engaged in toxicology analysis and the quantification of drugs. 'e"Maria Reid, Royal Canadian Mounted Police, Canadian Society of Forensic Science, Vol. 43, No. 1, March 2010 The book is of obvious utility to those analysts who work in drug analysis and to those who are confronted occasionally with a drug-analysis problem. The strategies outlined in this work are important to anyone who is conducting trace analysis by chromatography coupled with mass spectrometry. 'e"Michael L. Gross, Journal of the American Society for Mass Spectrometry, The information presented in this book is definitely of value to any laboratory engaged in toxicology analysis and the quantification of drugs. -Maria Reid, Royal Canadian Mounted Police, Canadian Society of Forensic Science, Vol. 43, No. 1, March 2010 The book is of obvious utility to those analysts who work in drug analysis and to those who are confronted occasionally with a drug-analysis problem. The strategies outlined in this work are important to anyone who is conducting trace analysis by chromatography coupled with mass spectrometry. -Michael L. Gross, Journal of the American Society for Mass Spectrometry, The information presented in this book is definitely of value to any laboratory engaged in toxicology analysis and the quantification of drugs. --Maria Reid, Royal Canadian Mounted Police, Canadian Society of Forensic Science, Vol. 43, No. 1, March 2010 The book is of obvious utility to those analysts who work in drug analysis and to those who are confronted occasionally with a drug-analysis problem. The strategies outlined in this work are important to anyone who is conducting trace analysis by chromatography coupled with mass spectrometry. --Michael L. Gross, Journal of the American Society for Mass Spectrometry, The information presented in this book is definitely of value to any laboratory engaged in toxicology analysis and the quantification of drugs. e"Maria Reid, Royal Canadian Mounted Police, Canadian Society of Forensic Science, Vol. 43, No. 1, March 2010 The book is of obvious utility to those analysts who work in drug analysis and to those who are confronted occasionally with a drug-analysis problem. The strategies outlined in this work are important to anyone who is conducting trace analysis by chromatography coupled with mass spectrometry. e"Michael L. Gross, Journal of the American Society for Mass Spectrometry, The information presented in this book is definitely of value to any laboratory engaged in toxicology analysis and the quantification of drugs. "Maria Reid, Royal Canadian Mounted Police, Canadian Society of Forensic Science, Vol. 43, No. 1, March 2010 The book is of obvious utility to those analysts who work in drug analysis and to those who are confronted occasionally with a drug-analysis problem. The strategies outlined in this work are important to anyone who is conducting trace analysis by chromatography coupled with mass spectrometry. "Michael L. Gross, Journal of the American Society for Mass Spectrometry

Dewey Edition22

IllustratedYes

Dewey Decimal615/.1901

Table Of ContentPart One. Isotopically Labeled Analog as Internal Standard for Drug Quantitation -- Methodology Quantitation of Drug in Biological Specimen -- Isotopically Labeled Analog of the Analyte as Internal Standard Introduction Significance of Accurate Quantitation Preferred Calibration Method Internal Standard and Quantitation Ions Inadequate Isotopic Purity -- An Extrinsic Factor Cross-Contribution Derived from Ion Fragmentation Mechanism -- An Intrinsic Factor Fitting Calibration Data 2H- Versus 13C-Analogs as Internal Standards Concluding Remarks References Isotopically Labeled Analog of the Analyte as Internal Standard for Drug Quantitation -- Chemical Derivatization and Data Collection and Evaluation Introduction Chemical Derivatization Production of Most Favorable Ion-Pairs for Drug Quantitation Exemplar Studies Isotopically Labeled Analogs and Chemical Derivatization Groups Ion Intensity Cross-Contribution Data Full-Scan Mass Spectra Selected Ion Monitoring and Calculation of Cross-Contribution Data: Direct Measurement, Normalized Direct Measurement, Internal Standard Method, Standard Addition Method Assessing the Accuracy of Empirically Determined Cross-Contribution Data: Experimentally Observed Concentration, Theoretically Calculated Concentration, Comparing Empirically Derived and Theoretically Calculated Concentrations -- Graphic Presentation, Summary Compilation of Full-Scan Mass Spectra and Ion Intensity Cross-Contribution Tables: Derivatization Procedures, Instrumentation, and Analytical Parameters Collection of Mass Spectrometric Data Ion Intensity Cross-Contribution Data Concluding Remarks References Part Two. Mass Spectra of Commonly Abused Drugs and Their Isotopically Labelled Analogs in Various Derivatization Forms Table of Contents for Appendix One Stimulants Opioids Hallucinogens Depressants/Hypnotics Antianxiety Agents Antidepressants Others Part Three. Cross-Contributions of Ion Intensity Between Analytes and Their Isotopically Labeled Analogs in Various Derivatization Forms Table of Contents for Appendix Two Stimulants Opioids Hallucinogens Depressants/Hypnotics Antianxiety Agents Antidepressants Others Index

SynopsisWith more than1500 full scan mass spectra and quick access data tables, this text provides the first such reference for labs involved in the analysis of abused and therapeutic drugs. Part one illustrates approaches, mechanisms, and challenges pertaining to the use of isotopic analogs as internal standards for drug quantification. A second part compiles mass spectra, including drugs and their analogs, as parent compounds and as derivatives resulting from those approaches commonly adapted in today's labs. Based on data from the second part, the third part provides corresponding tables of ion-pairs that can potentially be adapted to designate the drugs and their analogs in the analytical processes., The analysis of drugs and their metabolites in biological media are now expected to routinely achieve 20% accuracy in the ng/mL concentration level. Therefore, the availability and the selection of quality ion-pairs designating the analytes and their isotopically labeled analogs (ILAs) are important considerations in achieving the accuracy of quantitation results. Assisting scientists with this process, Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs provides an extremely valuable reference for labs involved in the analysis of therapeutic and abused drugs. Part One of this comprehensive volume illustrates approaches, mechanisms, and challenges pertaining to the use of isotopic analogs as internal standards for drug quantitation. The second section is a systematic compilation of full-scan mass spectra of drugs and their analogs, as parent compounds and as derivatives resulting from various chemical derivatization approaches, commonly encountered in today's labs. Based on the mass spectra data presented in the second section, Part Three provides corresponding tables of ion-pairs which can potentially be adapted to designate the drugs and their isotopic analogs in the analytical processes. Relative quality of these ion-pairs (cross-contribution to the intensity of these ions by their isotopic analogs) is included in these tables. With more than 1500 full-scan mass spectra and quick access data tables, this text represents the authors' years of work compiling mass spectra of the many chemical derivatization forms of drugs, their metabolites, and their isotopically labeled counterparts. The unparalleled scope of this compilation makes it a critical one-stop reference for those involved in drug analyses of biological specimens and interpretation of results., The analysis of drugs and their metabolites in biological media are now expected to routinely achieve ± 20% accuracy in the ng/mL concentration level. Therefore, the availability and the selection of quality ion-pairs designating the analytes and their isotopically labeled analogs (ILAs) are important considerations in achieving the accuracy of quantitation results. Assisting scientists with this process, Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs provides an extremely valuable reference for labs involved in the analysis of therapeutic and abused drugs. Part One of this comprehensive volume illustrates approaches, mechanisms, and challenges pertaining to the use of isotopic analogs as internal standards for drug quantitation. The second section is a systematic compilation of full-scan mass spectra of drugs and their analogs, as parent compounds and as derivatives resulting from various chemical derivatization approaches, commonly encountered in today's labs. Based on the mass spectra data presented in the second section, Part Three provides corresponding tables of ion-pairs which can potentially be adapted to designate the drugs and their isotopic analogs in the analytical processes. Relative quality of these ion-pairs (cross-contribution to the intensity of these ions by their isotopic analogs) is included in these tables. With more than 1500 full-scan mass spectra and quick access data tables, this text represents the authors' years of work compiling mass spectra of the many chemical derivatization forms of drugs, their metabolites, and their isotopically labeled counterparts. The unparalleled scope of this compilation makes it a critical one-stop reference for those involved in drug analyses of biological specimens and interpretation of results.

LC Classification NumberRS189