Über dieses Produkt

Product Identifiers

PublisherWiley & Sons, Incorporated, John

ISBN-10352731444X

ISBN-139783527314447

eBay Product ID (ePID)4038592115

Product Key Features

Number of Pages1018 Pages

Publication NameWay of Synthesis : Evolution of Design and Methods for Natural Products

LanguageEnglish

Publication Year2007

SubjectChemistry / Physical & Theoretical, Life Sciences / Biology, Chemistry / Organic

TypeTextbook

Subject AreaScience

AuthorTomas Hudlicky, Josephine W. Reed

FormatTrade Paperback

Dimensions

Item Height2 in

Item Weight67.6 Oz

Item Length9.5 in

Item Width6.8 in

Additional Product Features

Edition Number11

Intended AudienceScholarly & Professional

Dewey Edition22

Reviews"Hudlicky hat ein sehr persönliches Buch geschaffen, das sich an einigen Stellen spannend liest. Im Gegenzug zu Nicolaous "Classics in Total Synthesis" mit detaillierten Abhandlungen einiger Zwischenschritte wird in "The Way of Synthesis: Evolution of Design and Methods for Natural Products" eine eher gesamtheitliche Betrachtung gegeben, die auch vor philosophischen Fragestellungen nicht halt macht. Fortgeschrittene Studenten, die sich fragen, auf welchem Arbeitsgebiet sie promovieren wollen, werden genauso eine Antwort finden, wie Personen, welche sich für Taktiken und Strategien in der Totalsynthese interessieren." http://www.organische-chemie.ch/Buch/352731444X.htm Nov. 07 "Das Buch kann allen akademischen Wissenschaftlern im Bereich der organischen Chemie empfohlen werden, die Interesse an historischen Aspekten der Totalsynthese haben," Angewandte Chemie 2008/120/1, "Hudlick and Reed produced a fascinating read featuring numerous epigraphs, quotations, and personal remarks for synthetic chemists at all levels." ( CHOICE , February 2008) "...The Way of Synthesis provides much information for its price." ( Angewandte International Edition , December 2007), "...The Way of Synthesis provides much information for its price." ( Angewandte International Edition , December 2007)

TitleLeadingThe

Dewey Decimal547.2

Table Of ContentINTRODUCTION The History of Synthesis Milestones in Organic Sythesis STRATEGY AND TACTICS Principles and Issues Impacting Synthesis (Strategy) Principles and Issues Impacting Design (Strategy) Principles and Issues of Methods (Tactics) COMPARATIVE DESIGN: CLASSICS IN TERPENE SYNTHESIS Juvenile Hormones Cedrenes Zizaanes Hydroazulenes Vernolepin Triquinanes Compactin Aphidicolin Miscellaneous Diterpenes Taxol COMPARATIVE DESIGN: CLASSICS IN ALKALOID SYNTHESIS Lycopodium Alkaloids Daphniphyllum Alkaloids, Daphnilactone A Pyrrolizidine Alkaloids Amaryllidaceae Alkaloids Morphine Indole Alkaloids MISCELLANEOUS SYNTHESES Maytansine Palytoxin Brevetoxin B Indinavir OUTLOOK

SynopsisMehr als nur ein Lehrbuch der Naturstoffsynthese! Dieser Band erkundet verschiedene Synthesestrategien und vergleicht Herangehensweisen, die unabhängig von der jeweiligen Zielverbindung auf viele Synthesewege anzuwenden sind. Es enthält au erdem eine Zusammenstellung von Totalsynthesen sowie alternative Synthesemethoden für bestimmte Verbindungen. Die Autoren betrachten die Entwicklung der Naturstoffsynthese aus historischem Blickwinkel und arbeiten allgemeine Prinzipien heraus. Zu den behandelten Synthesen gehören Klassiker wie Terpene und Alkaloide, aber auch etliche andere interessante Beispiele wie Maytanise, Palytoxin, Brevatoxin B und Indinavir., For synthetic chemists of all levels, this textbook serves courses based on reactions, history, or design philosophy. Unique in including personal recollections from authors whose work is featured in the text, it contains discussion of tactics and strategies for total synthesis., At the heart of organic chemistry is the effective synthesis of natural products or compounds, which are important for pharmaceuticals and agrochemicals, for example. These syntheses often include new reactions and novel concepts in organic chemistry, such that there is always a need for innovative strategies and improved methods. This textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of total synthesis with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, whatever the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives. With its attractive layout highlighting key parts and tactics using a second color this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. A native of North Carolina, Josephine Reed was educated at the University of North Carolina at Greensboro (B.A., English), Appalachian State University (B.A., biology and chemistry), and Virginia Tech (Ph.D., chemistry). Besides her many, many years as a student, she has spent time as a department store clerk, a waitress, a banker, a bartender, and a chemistry instructor. She continues her eclectic career at Brock University in St. Catharines, Ontario, where she shares her life and her work with the co-author and their son. Still an English major at heart, Josie has always had a secret desire to be a writer, preferably a poet, and is delighted to be a part of the making of this book. Tomas Hudlicky was born and raised in Prague, Czechoslovakia and emigrated to the US in 1968. He received his PhD in 1977 under the direction of Professor Ernest Wenkert in the field of indole alkaloid total synthesis. He then spent a year at the University of Geneva working under the late Professor Wolfgang Oppolzer on the synthesis of isocomene. He began his academic career in 1978 at the Illinois Institute of Technology and moved to Virginia tech (1982) and to the University of Florida(1995). In 2003, he accepted an offer from Brock University where he currently holds the position of Canada Research Chair professor of Organic synthesis and Biocatalysis. His current research interests include the development of enantioselective synthetic methods, bacterial dioxygenase-mediated degradation of aromatics and isolation of chiral metabolites for use in asymmetric synthesis, design and synthesis of fluorinated inhalation anesthetic agents, synthesis of morphine and Amaryllidaceae alkaloids, organic electrochemistry, and design of unnatural oligo-saccharide conjugates and polymers with new molecular properties. His hobbies include martial arts, music, hockey, and skiing and he enjoys all of these with his 17 year old son Jason., This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. "I think, as will many organic chemists, that the Hudlicky book will be the Bible of synthetic organic chemistry, the past, the present and the future. A hallmark publication." (Victor Snieckus)

LC Classification NumberQD262